Senior Staff Engineer, Modeling and Data Applications

Position Objectives

The successful candidate will be part of the Data & Modeling Applications Group within Biotherapeutics Process Development and will support process development and optimization of production processes for biopharmaceuticals through modeling approaches.

Position Accountabilities

• Mechanistic modeling of upstream and downstream processes with simulation software applications to enhance model-based process development
• Modeling of process sustainability and economics of new or improved biopharmaceutical manufacturing platforms and fit into manufacturing facilities
• Perform multivariate process trending analysis in support of development and optimization of manufacturing processes for biopharmaceuticals and bioconjugates
• Model impact of innovative strategies on existing and new manufacturing processes
• Apply modeling approaches to process development including model transfer learning
• Provide modeling support for biopharmaceutical process characterization activities in preparation for process validation
• Evaluation of process and cost modeling software applications for use in biopharmaceutical development
• Collaboration with internal and external groups
• Represent the Process Development Department on various project teams
• Development of AI/ML model applications for hybrid models, and the exploration of innovative approaches to model building, including AI/ML techniques

Education, Experience and Skills

The preferred candidate holds a Ph.D. degree or a M.S. degree in biochemical engineering/biotechnology, data sciences, predictive modeling or closely related fields with 3+ years (PhD.) or 10+ years (M.S.) of experience in modeling and bioprocess development.

Requirements

• The open position requires hands-on experience in process modeling applications (such as gProms, GoSilico, BioSolve, SIMCA, etc.)
• Additional hands-on and lab-based process and/or high-throughput development experience is preferred
• The candidate should be familiar with cGMPs for biopharmaceuticals and regulatory submissions and show the ability to work well independently as well as a member of a team
• High communication skills, excellent written and verbal communication
• Programming skills (e.g. Matlab, Python)
• Ability to present findings clearly to non-technical stakeholders
• Ability to work in fast-paced environments
• Teamwork skills for working in a diverse, global environment
• Willingness to stay updated with the latest industry trends and technologies

Travel Requirements

May require approximately 10-20% travel