Site HSE Manager

Job Description Summary

The Manager, Health, Safety and Environment, is responsible for supporting the expansion of Durham campus operations to include Large Molecule drug substance production at our new facility in RTP, NC. This vital position will develop, implement, and track completion of HSE deliverables and needs (e.g., design input, construction safety, HSE operational readiness prior to the start of operations). The role will support overall project success, as well as ensure robust implementation of HSE systems, programs, and controls prior to start of operations. The role will be on the LMO SLT and act as primary point of contact to that platform providing expert support across HSE topics. This role will be the Functional Lead for Occupational Safety programs across the Durham campus's overall Gene Therapy/LMO/ADP operations. This role will lead implementation of robust HSE programs to ensure the protection of associated and the environment while simultaneously contributing to a strong, proactive, and enabling HSE culture.

Key Responsibilities

• Lead the design and implementation of robust HSE programs and controls to ensure safe and compliant start-up of LMO production operations.
• Integrate LMO-specific HSE requirements into site-wide frameworks, including processes, systems, and training programs.
• Partner with internal teams and external providers to deliver world-class safety performance, particularly across construction and operational activities.
• Serve as a trusted HSE advisor, providing expert guidance on risk management, regulatory compliance, and transparent reporting.
• Drive Occupational Safety excellence by leading critical programs such as Process Safety, Electrical Safety, Fire Protection, and Emergency Response.
• Collaborate cross-functionally to embed HSE priorities into daily operations, aligning with broader site strategy and performance goals.
• Establish and monitor HSE metrics and KPIs, delivering actionable insights to support continuous improvement and leadership reporting.
• Build HSE capabilities across the site through training, engagement initiatives, and strong safety governance structures.
• Ensure comprehensive risk assessments, hazard analysis, and technical evaluations for new operations, equipment, and materials.
• Champion a high-performance safety culture by leading audits, investigations, regulatory interactions, and continuous improvement initiatives.

Essential Requirements

• 8+ years of HSE program development/management experience in a manufacturing/laboratory environment, preferably within the biopharmaceutical industry.
• Bachelor's or Master's degree in Occupational Health & Safety, Environmental Science, Engineering, Biology, or related field.
• Professional HSE certifications (e.g., CSP, CIH or equivalent) highly desired.
• Prior experience supporting the design and startup of new LMO/ADP facilities and manufacturing operations (e.g., PHAs, P&ID/design documentation review, HSE operational readiness) highly desired.
• Outstanding interpersonal skills for coaching and collaboration.
• Ability to adapt communication styles based on audience and effectively advise on complex matters.
• Creative problem solver, strong multi-tasker, and excellent oral and written communication skills.