Summary

Prime Medicine is seeking an experienced, dependable and dedicated Associate Scientist / Senior Associate Scientist who is well-versed in Next Generation Sequencing with experience in a GMP environment to join the cross-collaborative and purpose-driven On-Target NGS team in supporting Prime Medicine's drug discovery and development pipeline. The role requires in-depth technical knowledge of and experience with NGS sample processing and Illumina sequencing. The successful candidate will support the implementation and optimization of automated NGS library workflows as well as Illumina sequencer operation. Experience in executing high-throughput genomics workflows for both GMP testing and R&D experiments is ideal.

Job description

Position Overview

Prime Medicine is seeking an experienced, dependable and dedicated Associate Scientist / Senior Associate Scientist who is well-versed in Next Generation Sequencing with experience in a GMP environment to join the cross-collaborative and purpose-driven On-Target NGS team in supporting Prime Medicine's drug discovery and development pipeline. The role requires in-depth technical knowledge of and experience with NGS sample processing and Illumina sequencing. The successful candidate will support the implementation and optimization of automated NGS library workflows as well as Illumina sequencer operation. Experience in executing high-throughput genomics workflows for both GMP testing and R&D experiments is ideal.

Responsibilities

Support the execution, development and validation of GMP and R&D NGS-based workflows.
Operation, regular maintenance and troubleshooting of automated liquid handlers and Illumina sequencers.
Tracking and documentation of instrument maintenance, NGS reagents, samples and sequencing QC metrics in LIMS systems.
Collaborate closely with R&D scientists, automation, informatics and bioinformatics to execute R&D sample submissions using high-throughput NGS.
Drive the transition of assays from development to production by working with members of the R&D and automation teams.
Perform other related duties and ad hoc projects as required by position and in support of the On-Target NGS team.

Qualifications

B.S./M.S. in molecular biology, biotechnology, or other relevant scientific degree.
4+ years of hands-on experience in NGS library preparation and sequencing.
2+ years of experience in a GMP lab.
Technical experience with Illumina sequencing platforms.
Experience using a LIMS system for sample tracking and processing and experimental documentation.
Excellent attention to detail and a commitment to producing high-quality NGS data.
Experience with laboratory automation, particularly NGS on liquid handlers, is a plus.
Assay validation and implementation experience, is a plus.

Requirements

B.S./M.S. in molecular biology, biotechnology, or other relevant scientific degree
4+ years of hands-on experience in NGS library preparation and sequencing
2+ years of experience in a GMP lab
Technical experience with Illumina sequencing platforms
Experience using a LIMS system for sample tracking and processing and experimental documentation
Excellent attention to detail and commitment to producing high-quality NGS data
Experience with laboratory automation, particularly NGS on liquid handlers (preferred)
Assay validation and implementation experience (preferred)

Benefits

Medical, Dental & Vision
Life Insurance
401(k) Matching
Equity Programs
Paid Time Off
Wellness Days
Company-wide Recharge Breaks
Short-term Incentive Award
Long-term Incentive Award

Company overview

Prime Medicine is a pioneering biotechnology company specializing in prime editing technology, a next-generation gene editing platform developed by Dr. David Liu. Based in Cambridge, Massachusetts, the company focuses on developing precise genetic therapies that can correct disease-causing mutations without creating double-strand DNA breaks, offering potentially safer and more versatile therapeutic applications compared to traditional CRISPR-Cas9 systems. Prime Medicine's innovative platform enables targeted correction of genetic errors across a broad spectrum of diseases, including both rare genetic disorders and more common conditions. The company's technology represents a significant advancement in the field of genetic medicine, with the potential to address previously untreatable genetic diseases through precise DNA modifications. Prime Medicine has attracted substantial scientific and investment interest due to the groundbreaking nature of its prime editing technology and the expertise of its founding team.