Sr Director - Operations
Eli Lilly and Company
Summary
Lilly is currently constructing an advanced manufacturing facility for the production of API molecules. This facility is intended to provide APIs for current and future products, including new modalities. This is a unique opportunity to be a part of the leadership team for the startup of a greenfield manufacturing site, and the successful candidate will help to build the organization, the facility and the culture to enable a successful startup into GMP manufacturing operations.
Job description
Position Overview
The Senior Director, Operations is responsible for leading manufacturing operations—either small molecule or siRNA/oligonucleotide—ensuring the organization has the capacity, capability, and leadership to deliver the site's manufacturing plan. This role also integrates cross-functional support teams and fosters a strong safety culture.
As a member of the Lilly Site Lead Team, the Senior Director contributes to strategic direction, organizational development, and cross-functional issue resolution.
During the project delivery and startup phase (2029–2030), the role will focus on:
- Supporting facility delivery and operational readiness.
- Building the manufacturing organization and leadership structure.
- Developing and implementing GMP systems and processes.
- Shaping site culture and ensuring alignment with long-term business goals.
Responsibilities
Pre-Startup and Startup Phase:
- Lead collaboratively and energetically across all aspects of operational readiness and startup.
- Build an organization with the capability, capacity, and culture to achieve high standards in safety, quality, and operational excellence.
- Develop and implement site systems and processes, drawing on internal expertise and external best practices.
- Embed lean principles and a continuous improvement mindset across operations and support functions.
- Act as the end-user representative during project delivery—providing input on design, commissioning, and startup decisions to ensure alignment with project goals and long-term strategy.
Post Startup:
- Develop and execute strategic and operational plans for Production Operations.
- Contribute to the site's medium- and long-term strategic direction.
- Ensure compliance with all applicable regulatory requirements (e.g., safety, quality/cGMP, environmental, financial, legal, HR).
- Ensure Production Flow and Process Teams meet Lilly's Manufacturing Standards for Operational Excellence.
- Maintain robust control systems to manage operations, identify compliance risks, and escalate issues appropriately.
- Monitor site and business area performance and take corrective action as needed.
- Lead cross-functional teams to implement new product introductions and continuous improvement initiatives.
- Develop future management and technical leaders for site and global roles.
Requirements
- Bachelor's degree in a relevant discipline
- 10+ years of experience leading operations within the pharmaceutical industry
Additional Preferences
- Experience in API manufacturing and Process Safety Management preferred.
- Strong knowledge of cGMPs and their application in manufacturing operations.
- Proven ability to build effective relationships across all organizational levels, including close collaboration with the Site Leadership Team.
- Demonstrated success in leading projects from initiation to completion—on time, within budget, and to high performance standards.
- Skilled in developing and managing high-performing, engaged teams with a strong safety and team-oriented culture.
Requirements
- Bachelor's degree in a relevant discipline
- 10+ years of experience leading operations within the pharmaceutical industry
- Experience in API manufacturing and Process Safety Management preferred
- Strong knowledge of cGMPs and their application in manufacturing operations
- Proven ability to build effective relationships across all organizational levels
- Demonstrated success in leading projects from initiation to completion
- Skilled in developing and managing high-performing, engaged teams
Benefits
- 401(k)
- Pension
- Vacation benefits
- Medical, Dental & Vision
- Prescription drug benefits
- Flexible spending accounts
- Life insurance
- Death benefits
- Employee assistance program
- Fitness benefits
- Employee clubs and activities
- Company bonus
Company overview
Eli Lilly and Company, commonly known as Lilly, is a leading American multinational pharmaceutical corporation headquartered in Indianapolis, Indiana. Founded in 1876 by Colonel Eli Lilly, the company has grown into one of the world's most valuable pharmaceutical enterprises, with operations in approximately 125 countries. Lilly specializes in developing and manufacturing innovative medicines across multiple therapeutic areas, including diabetes, oncology, neuroscience, immunology, and cardiometabolic diseases. The company is renowned for its groundbreaking work in insulin production, having been the first to mass-produce insulin and later developing the first commercially available insulin product in the U.S. Lilly's current portfolio includes blockbuster medications such as Mounjaro and Zepbound (tirzepatide) for diabetes and obesity, Trulicity (dulaglutide) for type 2 diabetes, Verzenio (abemaciclib) for breast cancer, and Taltz (ixekizumab) for autoimmune conditions. With approximately 47,000 employees worldwide, Lilly maintains a strong commitment to research and development, investing heavily in scientific innovation to address some of the world's most significant health challenges. The company operates with a mission to make life better for people around the world through the discovery and delivery of innovative medicines.