Sr. Research Associate, Protein Design

Here's What You'll Do

• Execute and optimize recombinant protein expression workflows in mammalian and bacterial (E. coli) expression systems.
• Perform transient mammalian cell culture and transfection for protein production.
• Conduct recombinant protein purification using chromatography-based methods including affinity, ion exchange, and size-exclusion chromatography utilizing FPLC systems.
• Support development and optimization of expression, purification, and formulation conditions for challenging proteins and complex antigens.
• Characterize proteins using biochemical and biophysical techniques including SDS-PAGE, western blotting, SEC-MALS, DSC, DSF, BLI, Mass Photometry, and flow cytometry-based approaches.
• Evaluate protein purity, stability, oligomeric state, aggregation, and biomolecular interactions to support candidate assessment and advancement.
• Analyze, interpret, and summarize experimental data and communicate findings through presentations, technical reports, and project team discussions.
• Develop and implement AI-assisted workflows for high-throughput protein screening and characterization.
• Leverage AI to accelerate analysis of protein screening datasets and identify high-performing candidates.
• Collaborate closely with scientists and cross-functional teams to support project goals, timelines, and deliverables.
• Identify technical challenges and troubleshoot protein expression, purification, and characterization workflows.
• Support implementation and evaluation of new protein production and characterization technologies to improve workflow efficiency.
• Maintain accurate experimental records and support inventory management, reagent tracking, and logistics coordination for partnered programs.

Here's What You'll Need (Basic Qualifications)

• Bachelor's degree in Biochemistry, Molecular Biology, Biomedical Science, Protein Engineering, Chemical Biology, or a related scientific discipline with 2+ years of relevant experience.
• Hands-on experience with recombinant protein expression in both mammalian and bacterial (E. coli) systems.

Here's What You'll Bring to the Table (Preferred Qualifications)

• Bachelor's degree in Biochemistry, Molecular Biology, Biomedical Science, Protein Engineering, Chemical Biology, or a related scientific discipline with 4+ years of relevant experience, or a Master's degree with 2+ years of relevant experience.
• Experience with protein purification workflows and operation of FPLC systems.
• Experience with biochemical and biophysical characterization methods including SDS-PAGE, western blotting, SEC-MALS, DSC, DSF, BLI, Mass Photometry, or related techniques.
• Demonstrated ability to troubleshoot and optimize protein expression, purification, and characterization workflows.
• Experience analyzing protein quality, stability, aggregation, and biomolecular interactions.
• Strong quantitative data analysis and scientific problem-solving skills with attention to detail.
• Ability to manage multiple experiments and priorities in a collaborative, cross-functional research environment.
• Excellent written and verbal communication skills.