Sr Scientist
Amgen
Summary
We are seeking a motivated Senior Scientist in mass spectrometry–based proteomics to join our talented and collaborative team in Thousand Oaks, CA. In this vital role, you will deliver critical insights to support target identification and drug discovery, while advancing innovative proteomics platform technologies.
Job description
You will contribute to both pipeline advancement and screening platform innovation by developing and implementing cutting-edge, high-throughput proteomics approaches. This includes executing automated sample preparation and mass spectrometry analyses across a range of assays, as well as designing, optimizing, and continuously enhancing next-generation screening workflows and analytical platforms.
This role requires hands-on experience operating and troubleshooting high-throughput mass spectrometry systems. Your work will play a key role in enabling innovative drug screening strategies, accelerating discovery efforts, and strengthening pipeline support.
What you will do
- Design, develop, and optimize high-throughput mass spectrometry–based proteomics workflows and screening platforms to accelerate drug discovery
- Execute automated sample preparation and LC-MS/MS analysis across a broad range of high-throughput proteomics assays
- Collaborate closely with chemistry, biology, and disease area teams as a technical and scientific subject matter expert, contributing to data-driven decision-making
- Perform data analysis and generate insights into mechanism of action, target engagement, and selectivity using proteomics approaches
- Present research findings at internal and external meetings and effectively communicate plans, results, and analyses to cross-functional teams
- Maintain accurate and organized documentation of experiments, protocols, and analyses
Basic Qualifications
- Doctorate degree (PhD, PharmD, or MD) with relevant experience OR
- Master’s degree and 4 years of directly related experience OR
- Bachelor’s degree and 6 years of directly related experience
Preferred Qualifications
- Doctorate degree in proteomics, chemoproteomics, biochemistry, chemistry, or a related discipline
- Strong track record in developing mass spectrometry–based proteomics assays, operating advanced platforms (e.g., Orbitrap Astral), and analyzing proteomics data
- Experience with sample preparation miniaturization and automation platforms
- 3+ years of experience in the biotech or pharmaceutical industry
- Demonstrated innovation in assay, method, or platform development
- Strong quantitative and computational expertise in high-dimensional proteomics data analysis
- Ability to work effectively in a highly integrated, collaborative team environment, with excellent organizational, verbal, and written communication skills, and a proven track record of producing reliable and reproducible results.
- Knowledge of targeted protein degradation or E3 ligase biology is a plus
Requirements
- Doctorate degree (PhD, PharmD, or MD) with relevant experience OR Master’s degree and 4 years of directly related experience OR Bachelor’s degree and 6 years of directly related experience
- Hands-on experience operating and troubleshooting high-throughput mass spectrometry systems
- Expertise in mass spectrometry–based proteomics assay development
- Experience with automated sample preparation and LC-MS/MS analysis
- Strong data analysis skills for proteomics data
- Ability to collaborate with cross-functional teams
- Excellent organizational, verbal, and written communication skills
Benefits
- 401(k) with company contributions
- Medical, Dental & Vision
- Life & Disability Insurance
- Flexible Spending Accounts
- Annual Bonus Program
- Stock-based Long-term Incentives
- Paid Time Off
Company overview
Amgen Inc. is a leading American multinational biopharmaceutical company headquartered in Thousand Oaks, California, founded in 1980. As one of the world's largest independent biotechnology companies, Amgen specializes in discovering, developing, manufacturing, and delivering innovative human therapeutics. The company focuses on six key therapeutic areas: inflammation, oncology/hematology, bone health, cardiovascular disease, nephrology, and neuroscience. Amgen's portfolio includes blockbuster drugs such as Enbrel for autoimmune diseases, Prolia and XGEVA for osteoporosis, Repatha for cholesterol management, Otezla for psoriasis, and Neulasta for chemotherapy-induced neutropenia. With approximately 28,000 employees worldwide, Amgen operates as a component of both the Dow Jones Industrial Average and Nasdaq-100 indices. The company maintains a robust research and development pipeline with numerous clinical programs across various stages, leveraging cutting-edge biotechnology and human genetic data to address some of the world's most challenging diseases. Amgen's manufacturing capabilities span multiple global locations, and it distributes products through pharmaceutical wholesale distributors and direct-to-consumer channels.