Sr Scientist, Biology
Gilead Sciences
Summary
We are seeking a talented and motivated Senior Scientist to join the Discovery Sciences & Technologies (DST) group and advance drug discovery programs across Virology, Inflammation, and Oncology. DST designs and executes rigorous, quantitative, and physiologically relevant biochemical, biophysical, and cellular assays to support target validation, lead identification, lead optimization, candidate selection, and exploratory biomarker development. The successful candidate will represent DST on multidisciplinary project teams as a subject-matter expert in the in vitro pharmacology of small and large molecules. This individual will independently develop and apply mechanistic assay strategies, generate decision-enabling data, and influence project direction across multiple modalities and therapeutic areas.
Job description
Key Responsibilities
- Develop fit-for-purpose screening and profiling cascades that enable lead identification, lead optimization, and candidate selection.
- Design, execute, and troubleshoot biochemical, biophysical, and cell-based assays that address critical project questions.
- Conduct mechanistic studies to characterize pharmacology, mechanism of action, selectivity, and target engagement.
- Independently analyze complex datasets, draw scientifically rigorous conclusions, and recommend actionable next steps.
- Serve as the DST functional-area expert on cross-functional project teams and influence program strategy through high-quality scientific guidance.
- Communicate results, interpretations, risks, and recommendations clearly to project teams, stakeholders, and senior leadership.
- Identify and implement emerging technologies and scientific approaches that strengthen DST capabilities and improve project execution.
Basic Qualifications
- 8+ Years with BS
- 6+ Years with MS
- 2+ Years with PhD
Preferred Qualifications
- Ph.D. in Pharmaceutical Sciences, Biochemistry, Cell Biology, or a related field, with at least three years of drug discovery experience in a biopharmaceutical industry environment.
- Demonstrated expertise in developing and deploying robust biochemical and cellular assays for target validation, lead generation, and structure–activity relationship-driven optimization.
- Strong knowledge of quantitative pharmacology, experimental design, data interpretation, assay troubleshooting, and rigorous laboratory documentation.
- Demonstrated ability to manage multiple priorities, deliver high-quality results in a fast-paced research environment, and operate effectively with a high degree of independence.
- Excellent written and verbal communication skills, with the ability to collaborate across disciplines, influence project decisions, and present effectively to senior leadership.
- Experience supporting lead identification or optimization programs for small molecules, large molecules, or both.
- Experience with integrated laboratory automation, high-throughput screening instrumentation, and data-intensive assay workflows.
- Experience defining project assay strategy, applying orthogonal methods, or characterizing mechanism of action and target engagement.
Requirements
- 8+ Years with BS
- 6+ Years with MS
- 2+ Years with PhD
- Ph.D. in Pharmaceutical Sciences, Biochemistry, Cell Biology, or a related field
- At least three years of drug discovery experience in a biopharmaceutical industry environment
- Demonstrated expertise in developing and deploying robust biochemical and cellular assays for target validation, lead generation, and structure–activity relationship-driven optimization
- Strong knowledge of quantitative pharmacology, experimental design, data interpretation, assay troubleshooting, and rigorous laboratory documentation
- Demonstrated ability to manage multiple priorities, deliver high-quality results in a fast-paced research environment, and operate effectively with a high degree of independence
- Excellent written and verbal communication skills, with the ability to collaborate across disciplines, influence project decisions, and present effectively to senior leadership
- Experience supporting lead identification or optimization programs for small molecules, large molecules, or both
- Experience with integrated laboratory automation, high-throughput screening instrumentation, and data-intensive assay workflows
- Experience defining project assay strategy, applying orthogonal methods, or characterizing mechanism of action and target engagement
Benefits
- Medical, Dental & Vision
- Life Insurance
- Paid Time Off
- Annual Bonus
- Stock-Based Long-Term Incentives
Company overview
Gilead Sciences, Inc. is a leading American biopharmaceutical company headquartered in Foster City, California, that specializes in researching, developing, and commercializing innovative medicines for life-threatening diseases. Founded in 1987, Gilead has grown into a global healthcare leader with approximately 17,600 employees worldwide. The company's primary therapeutic focus areas include HIV/AIDS, viral hepatitis (hepatitis B and C), oncology, inflammation, and respiratory diseases. Gilead is renowned for its groundbreaking antiviral therapies, including Sovaldi and Harvoni for hepatitis C, and its comprehensive portfolio of HIV treatments such as Truvada, Atripla, and Biktarvy. The company also developed Veklury (remdesivir) for COVID-19 treatment. Gilead operates as a publicly traded company on the NASDAQ (GILD) and is a component of both the Nasdaq-100 and S&P 100 indices. Through strategic acquisitions like Kite Pharma and Immunomedics, Gilead has expanded into cell therapy and oncology, demonstrating its commitment to advancing medical science and improving patient outcomes globally.