Sr. Scientist I (Immunology) - in vitro & in vivo studies
ModeX Therapeutics
Summary
ModeX Therapeutics is seeking a highly skilled and motivated Senior Scientist with experience in immunology to support the development and progression of new immune therapies. The successful candidate will work with ModeX's team to test novel biologic drug candidates, delineate their mechanism of action, and address biological questions. This is an exciting opportunity to be part of a cross-functional team and contribute to the development of next-generation therapeutics in a fast-paced, rapidly growing biotech company with a bold vision.
Job description
Key Responsibilities
- Play a key role in the development of new biologic drugs for immunotherapy
- Independently propose, plan and perform in vitro and in vivo studies to characterize the company's drug candidates and their mechanism of action
- Establish mechanistic insights addressing the impact of novel targets on immune responses
- Develop and perform complex functional assays using primary immune cells (human, mouse, NHP)
- Design, develop, troubleshoot and establish in vitro assays and in vivo models and standard operating procedures as needed
- Collaborate cross-functionally with project teams to ensure data-driven decision-making and timely progression of programs
- Contribute to scientific communications, including internal reports and presentations
Qualifications
- B.S. or M.S. in immunology, immune-oncology or related field
- Sr. Scientist I: 15+ years of relevant research experience; must have industry experience (10+ years)
- Strong, hands-on expertise in immunology and immunotherapy, with the ability to independently evaluate and apply new concepts and immunoassays
- Demonstrate mastery of complex functional assays using primary immune cells, including multi-color flow cytometry, ELISA and Luminex
- Extensive experience with in vivo studies, including mouse handling, multiple dosing routes (IV, IP, SC), tumor models, and tissue collection
- Proven ability to work independently, prioritize effectively, and drive projects forward in a fast-paced biotech environment
- Excellent written and oral communication, organization, and data analysis skills
- Outstanding troubleshooting and problem-solving skills
- Highly collaborative mindset, with the confidence to contribute new ideas and mentor junior team members as needed
Requirements
- B.S. or M.S. in immunology, immune-oncology or related field
- 15+ years of relevant research experience
- 10+ years of industry experience
- Strong, hands-on expertise in immunology and immunotherapy
- Mastery of complex functional assays using primary immune cells, including multi-color flow cytometry, ELISA and Luminex
- Extensive experience with in vivo studies, including mouse handling, multiple dosing routes (IV, IP, SC), tumor models, and tissue collection
- Proven ability to work independently, prioritize effectively, and drive projects forward in a fast-paced biotech environment
- Excellent written and oral communication, organization, and data analysis skills
- Outstanding troubleshooting and problem-solving skills
- Highly collaborative mindset, with the confidence to contribute new ideas and mentor junior team members
Company overview
ModeX Therapeutics is a clinical-stage biopharmaceutical company dedicated to developing innovative multispecific biologics for cancer and infectious diseases. Founded in 2020 by eminent medical innovators including Gary Nabel and Elias Zerhouni, the company operates as a wholly owned subsidiary of OPKO Health. ModeX's proprietary platforms unite the power of multiple biologics in a single molecule to create multispecific antibodies and vaccines with unprecedented versatility and potency against complex diseases. The company's MSTAR (Synergistic Targeting of Antigens and Receptors) platform enables the development of multispecific antibodies that can engage multiple targets simultaneously, offering enhanced therapeutic efficacy. ModeX's pipeline includes candidates targeting both solid and liquid tumors, as well as several of the world's most pressing viral threats including HIV, COVID-19, and Epstein-Barr virus. The company has established strategic collaborations with industry leaders such as Regeneron and Merck, and has secured significant funding from BARDA for infectious disease programs. Based in Weston, Massachusetts, ModeX employs approximately 51-200 professionals and has advanced multiple candidates into clinical trials, positioning itself as a leader in next-generation multispecific biologic development.