Sr. Scientist
Inotiv
Summary
The Senior Method Development Scientist will perform method development utilizing contemporary mass spectrometry techniques (LC-MS/MS & HRMS) for large and small molecules (proteins, antibodies, ADCs, oligonucleotides, etc.). The senior method development scientist will be a member of the DMPK team and will serve as a subject matter expert for new proposals, evaluating feasibility of LC-MS/MS method development, and troubleshooting challenging methods across a wide variety of species and matrices.
Job description
Essential Duties and Responsibilities
- Develop highly sensitive LC-MS/MS and HRMS methods for large (oligonucleotides, proteins, antibodies, ADCs, biomarkers, etc) and small molecules in biological matrices.
- Utilize and interpret scientific theories, concepts, techniques in bioanalytical and mass spectrometry studies and accepts leadership role in developing novel scientific approaches
- Coordinate, facilitate, and implement intercompany method transfers and implementation of incoming transfers from clients.
- Communicate project timelines, status, and data to Principal Investigators, Project Management, and clients effectively addressing any issues that may arise.
- Ability to coordinate and execute on multiple projects simultaneously and responsive to unscheduled deadlines and client needs.
- Demonstrate an understanding of Best Practices, SOPs and Good Laboratory Practice Regulations (21 CFR, Part 58) as these relate to study-specific services provided, this job description, and general facility operations.
- Training and mentoring junior scientists within and across departments
- Collaborate with leadership on long-range planning and strategy for departmental growth
- Performs other duties as assigned.
Skills and Abilities
- Experience, skills, and abilities must include knowledge of contemporary bioanalytical techniques, including wet chemistry separations, liquid chromatography, and mass spectrometric analysis (LC-MS/MS, HRMS), instrument operation, maintenance, and data processing.
- Proven track record of method development for large and small molecules
- Ability to incorporate software in the maintenance of databases to collate and catalog records and inventory.
- Working knowledge of laboratory software, system software, and Microsoft applications
- Independence in the laboratory and data work-up phases of research.
- A working knowledge and awareness of general laboratory procedures.
- Good written and oral communication skills.
- Ability to adhere to all safety regulations and procedures.
Education and Experience
- PhD in Organic Chemistry, Biochemistry, Analytical Chemistry or related discipline with 2+ years of industrial bioanalytical experience following Post Doctoral training
- M.Sc. in a discipline previously described with 5+ years direct industrial bioanalytical experience
- Candidates possessing working knowledge of in vitro metabolism/biotransformation, Pharmacokinetic modeling, analysis, interpretation and simulation desirable
Requirements
- PhD in Organic Chemistry, Biochemistry, Analytical Chemistry or related discipline with 2+ years of industrial bioanalytical experience following Post Doctoral training
- M.Sc. in a discipline previously described with 5+ years direct industrial bioanalytical experience
- Knowledge of contemporary bioanalytical techniques, including wet chemistry separations, liquid chromatography, and mass spectrometric analysis (LC-MS/MS, HRMS), instrument operation, maintenance, and data processing
- Proven track record of method development for large and small molecules
- Ability to incorporate software in the maintenance of databases to collate and catalog records and inventory
- Working knowledge of laboratory software, system software, and Microsoft applications
- Independence in the laboratory and data work-up phases of research
- A working knowledge and awareness of general laboratory procedures
- Good written and oral communication skills
- Ability to adhere to all safety regulations and procedures
- Understanding of Best Practices, SOPs and Good Laboratory Practice Regulations (21 CFR, Part 58)
Benefits
- Health insurance
- Dental coverage
- Short-term disability
- Long-term disability
- Paid time off
- Paid parental leave
- 401(k) Matching
Company overview
Inotiv is a leading contract research organization (CRO) specializing in nonclinical research services for the pharmaceutical, biotechnology, and medical device industries. The company provides comprehensive solutions including discovery and safety assessment services, research models, and analytical support. Inotiv operates through two main segments: Research Models and Services (RMS) and Discovery and Safety Assessment (DSA). The RMS segment offers research models, including purpose-bred rodents and large research models, along with related services. The DSA segment provides drug discovery and development services, including in vitro and in vivo studies, bioanalytical services, and regulatory support. With facilities across North America and Europe, Inotiv serves a global client base, supporting the development of new therapeutics from early discovery through regulatory submission. The company plays a critical role in advancing biomedical research by providing essential preclinical data and models that help accelerate the development of new drugs and medical treatments.