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Staff Security Engineer

Guardant Health

Any City, USHybridPosted 5 days ago$133,960 - $195,030
Full TimeSenior LevelTech & Data (Health IT)Diagnostics
Original posting ↗

Summary

The Staff Security Engineer, reporting to the Associate Director of Security Engineering, will be responsible for strengthening Guardant Health's ability to detect, investigate, and respond to threats. This role focuses on detection engineering, threat intelligence, security automation, and incident response, with an emphasis on infrastructure, cloud, endpoint, and identity security. You will be a hands-on technical leader working across Security Operations and Security Engineering disciplines to evolve how Guardant Health detects and responds to threats.

Job description

Duties and Responsibilities

  • Develop and maintain high-fidelity threat detection content, including rules, analytics, and behavioral detections across infrastructure, endpoint, cloud, SaaS and identity platforms.
  • Own and enhance detection engineering workflows, including testing, tuning, false-positive reduction, and coverage analysis.
  • Partner closely with external MDR provider to develop and refine detection rules, improve investigation quality, and establish effective escalation and response workflows.
  • Support and participate in incident response, including investigation, containment, eradication, and post-incident reviews.
  • Build dashboards, metrics, and reports to measure detection coverage, SOC effectiveness, and security posture.
  • Monitor and help secure AWS and cloud-native environments, including CloudTrail, VPC Flow Logs, workload logs, and SaaS integrations.
  • Evaluate and implement AI-assisted security capabilities for defense and detection, while also defining how AI systems, agents, and usage are logged, monitored, and assessed for risk.
  • Develop documentation, runbooks, and operational playbooks for SOC and security engineering workflows.
  • Mentor junior engineers and provide technical leadership within the SOC and security engineering functions.
  • Stay current on emerging threats, detection techniques, attacker tradecraft, and security data engineering best practices.

Qualifications

  • 8+ years of experience in security engineering, security operations, detection engineering, or incident response.
  • Strong hands-on experience developing, testing, and tuning SIEM and EDR detections across multiple environments.
  • Strong background in threat detection and incident response within a SOC environment.
  • Experience owning open source threat intelligence platforms such as MISP, Yeti, and OpenCTI.
  • Demonstrated ability to improve alert quality, reduce false positives, and incorporate business context into detection and response decisions.
  • Experience working with external MDR providers, managed SOCs, or SIEM service partners to improve detection content, investigations, escalations, and response outcomes.
  • Strong incident response experience, including leading technical investigations and coordinating containment, eradication, and recovery activities.
  • Hands-on experience with EDR platforms.
  • Experience working with identity and access logs.
  • Experience investigating threats in AWS environments and working with cloud security telemetry.
  • Understanding of AI and machine-learning use cases in security, including detection, automation, and governance considerations.
  • Strong written and verbal communication skills including ability to write threat intelligence assessments and reports.
  • Ability to work independently and collaboratively in a fast-paced environment.

Preferred Qualifications

  • Experience with detection engineering frameworks (e.g., Diamond Model, MITRE ATT&CK).
  • Experience in healthcare, biotech, or other regulated environments.
  • Security certifications such as CISSP, GIAC, GCED, GCIA, or cloud security certifications.

Requirements

  • 8+ years of experience in security engineering, security operations, detection engineering, or incident response
  • Strong hands-on experience developing, testing, and tuning SIEM and EDR detections across multiple environments
  • Strong background in threat detection and incident response within a SOC environment
  • Experience owning open source threat intelligence platforms such as MISP, Yeti, and OpenCTI
  • Demonstrated ability to improve alert quality, reduce false positives, and incorporate business context into detection and response decisions
  • Experience working with external MDR providers, managed SOCs, or SIEM service partners
  • Strong incident response experience, including leading technical investigations and coordinating containment, eradication, and recovery activities
  • Hands-on experience with EDR platforms
  • Experience working with identity and access logs
  • Experience investigating threats in AWS environments and working with cloud security telemetry
  • Understanding of AI and machine-learning use cases in security, including detection, automation, and governance considerations
  • Strong written and verbal communication skills
  • Ability to work independently and collaboratively in a fast-paced environment

Company overview

Guardant Health, Inc. is a leading precision oncology company headquartered in Palo Alto, California, focused on transforming cancer care through advanced blood and tissue testing technologies. Founded in 2012 by Helmy Eltoukhy and AmirAli Talasaz, who serve as co-CEOs, the company specializes in liquid biopsy tests that detect cancer from circulating tumor DNA in blood samples. Guardant Health's flagship product, Guardant360, was the first comprehensive liquid biopsy test approved by the FDA for tumor mutation profiling and companion diagnostics in non-small cell lung cancer. The company has expanded its portfolio to include Guardant Reveal for residual disease monitoring, Guardant360 TissueNext tissue testing, and Shield, the first FDA-approved blood test for colorectal cancer screening. Guardant Health operates globally with approximately 1,999 employees and generates revenue from precision oncology testing services for clinical and biopharmaceutical customers, as well as development services and technology licensing. The company's innovative approach enables earlier cancer detection, treatment selection, and monitoring, helping to improve patient outcomes across all stages of cancer care.

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