Structural Biologist III
Tempus AI
Summary
The Structural Biologist III collaborates across biology, bioinformatics, software engineering, and clinical teams to design tools and methodologies leveraging biomolecular structural data to guide clinical decisions.
Job description
Role Overview
The Structural Biologist III collaborates across biology, bioinformatics, software engineering, and clinical teams to design tools and methodologies leveraging biomolecular structural data to guide clinical decisions.
Key Responsibilities
- Provide structural biology support for variant analyses through structure-function relationship interpretation.
- Develop novel methods, protocols, and tools for structural modeling, molecular dynamics, and clinical variant assessment on internal platforms.
- Partner with statisticians and data scientists to validate algorithms and data collection workflows.
- Coordinate cross-functional efforts across Bioinformatics, R&D, and reporting teams for clinical research projects.
- Write testable, production-grade code adhering to SDLC standards and code review best practices.
- Maintain technical documentation, SOPs, and knowledge bases while mentoring junior staff.
- Direct and lead the structural team through both soft and explicit leadership ensuring timely project completion.
- Support, inform, and educate leadership and stakeholders about project progress and blockers.
Qualifications & Competencies
- Education: PhD in computational biology, structural biology, biophysics, bioinformatics, or equivalent.
- Experience: Minimum 5 years of R&D experience in computational structural biology or related fields, including at least 2 years of post-doctoral or industrial experience and 2 years management experience.
- Technical Skills: Fluency/proficiency in scripting/languages (Python, R, Perl, C/C++, Java, SQL) and bioinformatics/modeling software. Strong background in systems biology, molecular dynamics, and experimental techniques (X-ray, Cryo-EM).
Requirements
- PhD in computational biology, structural biology, biophysics, bioinformatics, or equivalent
- Minimum 5 years of R&D experience in computational structural biology or related fields
- At least 2 years of post-doctoral or industrial experience
- 2 years management experience
- Fluency/proficiency in scripting/languages (Python, R, Perl, C/C++, Java, SQL)
- Bioinformatics/modeling software proficiency
- Strong background in systems biology
- Strong background in molecular dynamics
- Experimental techniques (X-ray, Cryo-EM)
Company overview
Tempus AI, Inc. (NASDAQ: TEM) is a pioneering healthcare technology company founded in 2015 by Eric Lefkofsky in Chicago, Illinois. The company was established after Lefkofsky's wife was diagnosed with breast cancer, driving his mission to revolutionize cancer care through technology and artificial intelligence. Tempus specializes in applying AI to advance precision medicine by collecting and analyzing vast amounts of molecular, clinical, and genomic data. The company operates across multiple therapeutic areas including oncology, cardiology, radiology, neurology, psychiatry, and dermatology. Tempus provides comprehensive diagnostic services including next-generation sequencing (NGS), PCR profiling, and molecular pathology testing. Its AI-powered platform enables physicians to make real-time, data-driven decisions for personalized patient care and targeted therapies. The company went public in June 2024 and has expanded globally with operations in multiple countries. Tempus continues to innovate at the intersection of healthcare and artificial intelligence, aiming to ensure patients receive the right treatments at the right time for improved health outcomes.