Vice President, IT Resilience & Trust
Madrigal Pharmaceuticals
Summary
Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH). The Vice President, IT Resilience & Trust is a strategic and operational technology executive responsible for ensuring Madrigal's technology environment is reliable, resilient, secure, compliant, and able to scale with the business. Reporting to the Chief Information Officer, this leader will bring together Infrastructure & Reliability, Cybersecurity, and Technology Compliance under an integrated Resilience & Trust organization.
Job description
Key Responsibilities
Resilience & Trust Strategy
- Define and execute Madrigal's integrated Resilience & Trust strategy and multi-year roadmap across infrastructure, cybersecurity, technology compliance, service management, and resilience.
- Translate business growth, international expansion, regulatory requirements, technology trends, and emerging risks into clear priorities, standards, roadmaps, and investment decisions.
- Establish target architectures, operating principles, and risk-based technology guardrails that enable speed and innovation while maintaining appropriate reliability, security, compliance, and resilience.
- Partner with AI, digital, data, and other technology leaders to establish practical control, security, monitoring, and assurance expectations, and develop a repeatable technology foundation for global expansion.
- Establish a data-driven operating cadence across Resilience & Trust, manage investment tradeoffs, and serve as a trusted advisor to the CIO and IT Leadership Team.
Infrastructure & Reliability
- Provide executive leadership for infrastructure, workplace technology, enterprise service management, and technology operations.
- Define and evolve the strategy for cloud, networks, workplace, identity and access, endpoints, collaboration, and other foundational technology services.
- Build an enterprise-grade service management model and establish common ITSM practices across infrastructure, applications, digital products, data platforms, and key providers.
- Mature the ITSM platform, service ownership model, CMDB/service mapping, and core disciplines including incident, problem, change, request, knowledge, configuration, and service-level management.
- Establish measurable service levels, customer experience measures, observability, and operational health metrics.
- Own technology resilience and major incident management, including disaster recovery, RTO/RPO, dependency mapping, testing, cross-functional recovery coordination, and executive communication.
Cybersecurity & Technology Risk
- Provide executive accountability and strategic direction for Madrigal's cybersecurity program, leading the Head of Cybersecurity.
- Embed cybersecurity standards and controls into architecture, infrastructure, applications, vendors, acquisitions, international expansion, and major transformation initiatives.
- Establish cybersecurity and technology risk expectations for emerging technologies, including AI.
- Maintain effective oversight across identity and access, vulnerability management, monitoring, threat detection and response, endpoint and infrastructure security, sensitive information protection, and third-party technology risk.
- Ensure cyber risks and incidents are assessed, prioritized, communicated, and addressed based on business impact.
Technology Compliance & Governance
- Provide executive leadership for Madrigal's technology compliance capability and establish a scalable, risk-based control environment.
- Define governance frameworks, technology controls, standards, and operating practices that support regulatory requirements, company policies, and risk-management expectations.
- Partner closely with Quality to maintain appropriate lifecycle compliance for regulated and GxP technology systems, including CSV/CSA, 21 CFR Part 11, data integrity, validation, audit readiness, and inspection support.
- Partner with Finance, Internal Audit, Privacy, Legal, and other stakeholders to ensure technology controls supporting SOX, privacy, cybersecurity, data protection, and other enterprise requirements are clearly owned and effectively operated.
- Establish risk-based governance and meaningful measures of control effectiveness, compliance posture, remediation progress, technology risk, and audit/inspection readiness.
- Ensure material compliance risks and control deficiencies have clear owners, remediation plans, escalation paths, and timely closure.
Leadership, Capability Building & Cross Functional Partnership
- Lead, develop, and integrate the Infrastructure, Cybersecurity, and Technology Compliance leaders and teams into a cohesive Resilience & Trust organization.
- Raise the maturity of the organization through clear expectations for strategy, roadmaps, service ownership, metrics, risk management, executive communication, and continuous improvement.
- Develop functional leaders, assess organizational capability as needs evolve, and make appropriate changes to talent, structure, sourcing, and operating models.
- Manage budgets, investments, vendors, managed service providers, and resources across the Resilience & Trust portfolio.
- Partner across the IT Leadership Team and with International and other key stakeholders to embed reliability, cybersecurity, compliance, resilience, service management, and consistent technology standards into delivery and global growth.
- Provide clear executive visibility into service health, resilience, cybersecurity, compliance, significant incidents, risks, resource constraints, and investment needs.
Qualifications
Education: Bachelor's degree in Computer Science, Information Systems, Engineering, or a related discipline required. Advanced degree such as an MBA, MS, or related graduate degree preferred. An equivalent combination of education and highly relevant experience may be considered.
Experience: Prior experience serving as a Chief Information Security Officer (CISO) for a publicly traded company strongly preferred. Typically 20+ years of progressive technology leadership experience. Experience in a regulated environment; pharmaceutical, biotechnology, life sciences, healthcare, or another highly regulated industry strongly preferred.
Skills & Competencies: Strong executive presence, business judgment, and credibility with senior business and technology leaders. Enterprise-oriented thinker. Strong operational leader who establishes clear management systems, metrics, and accountability. Customer- and service-oriented. Effective leader of leaders. Strong collaborator and communicator.
Requirements
- Bachelor's degree in Computer Science, Information Systems, Engineering, or a related discipline required
- Advanced degree such as an MBA, MS, or related graduate degree preferred
- Prior experience serving as a Chief Information Security Officer (CISO) for a publicly traded company strongly preferred
- Typically 20+ years of progressive technology leadership experience
- Experience in a regulated environment; pharmaceutical, biotechnology, life sciences, healthcare, or another highly regulated industry strongly preferred
- Significant experience establishing or maturing enterprise technology operations and service management
- Demonstrated ability to define technology strategies, target-state roadmaps, architecture standards, governance mechanisms, and multi-year capability plans
- Strong understanding of enterprise infrastructure, cloud, workplace technology, identity and access, cybersecurity, disaster recovery, resilience, service management, governance, and regulated technology controls
- Experience operating technology control environments supporting GxP or other regulated activities
- Demonstrated experience leading major technology incidents, developing high-performing leaders and teams, managing significant budgets and external partners
- Strong executive presence, business judgment, and credibility with senior business and technology leaders
- Enterprise-oriented thinker who can connect business objectives, technology strategy, operational performance, risk, regulatory requirements, and investment decisions
- Strong operational leader who establishes clear management systems, metrics, and accountability
- Customer- and service-oriented
- Effective leader of leaders
- Strong collaborator and communicator
Benefits
- Hybrid work schedule
- Equity
- Flexible PTO
- Medical, Dental & Vision
- Life/Disability Insurance
- 401(k) Matching
- Supplemental Life Insurance
- Legal Services
- Employee Assistance Program
Company overview
Madrigal Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company focused on developing novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), formerly known as non-alcoholic steatohepatitis (NASH), a serious form of fatty liver disease. The company's lead product, Rezdiffra (resmetirom), is a once-daily, oral thyroid hormone receptor (THR)-β selective agonist that targets key underlying causes of MASH in the liver. Rezdiffra received FDA approval in 2024 as the first treatment for MASH with moderate to advanced liver fibrosis, representing a significant breakthrough in hepatology. Headquartered in Conshohocken, Pennsylvania, Madrigal is publicly traded on NASDAQ under the symbol MDGL. The company continues to advance its clinical development programs, including ongoing Phase 3 trials evaluating Rezdiffra for the treatment of compensated MASH cirrhosis. Madrigal's innovative approach addresses a critical unmet medical need in liver disease therapeutics.