Vice President, Manufacturing and Engineering

Essential Job Functions

• Executive Departmental Leadership: Provide strategic direction and executive management to four specialized functional leaders (Commercial Manufacturing, MS&T, Process Innovation & LCM, and Device Development). Drive cross-functional alignment and eliminate operational silos across the department.
• Multi-Disciplinary Product Strategy: Direct overarching operational strategies for a diverse product portfolio (small molecules, peptides, biologics) across varied dosage forms (oral solids, advanced injectables) from clinical phases through commercialization and Life Cycle Management.
• Outsourced Network Governance: Serve as the senior executive sponsor for Xeris's global network of Contract Manufacturing Organizations (CMOs). Establish and oversee strategies for vendor evaluation and selection, contract negotiations, capital expenditures, and vendor alliances to ensure capacity, quality, and financial efficiency.
• End-to-End Supply Chain Activities: Accountable for all aspects of Xeris's pharmaceutical supply chains ranging from raw materials to finished product inventories.
• Process Innovation & Life Cycle Management: Provide executive guidance and resource prioritization for complex, high-stakes technical initiatives, including the scale-up of novel formulation technologies (e.g., XeriJect) and commercial LCM projects (e.g., second sourcing, line extensions, etc.).
• Combination Product & Device Integration: Oversee the strategic intersection of Xeris's proprietary formulation platforms with advanced delivery devices, ensuring robust engineering frameworks, Design Controls, and seamless commercial execution.
• Regulatory Accountability: Maintain ultimate technical accountability for the manufacturing and device sections of global regulatory submissions (INDs, IMPDs, NDAs, BLAs, MAAs) and lead technical strategy during Health Authority interactions and Pre-Approval Inspections (PAIs).
• Strategic Financial Management: Drive goal setting, capacity planning, and overarching budget development across all four functional pillars, aligning departmental spending with corporate profitability targets.

Skills and Qualifications

• Bachelor's degree required, with a strong preference for Chemical Engineering. Degrees in Mechanical Engineering, Pharmaceutical Sciences, or related fields will be considered, commensurate with extensive, highly relevant operational experience.
• An advanced degree (M.S., Ph.D., or MBA) is strongly preferred.
• Minimum of 22+ years of experience in the pharmaceutical or biotechnology industry with a proven track record of executive leadership across manufacturing and engineering functions.
• Deep, hands-on expertise spanning a wide range of products (small molecules, peptides, biologics) and diverse dosage forms (oral solids, complex injectables).
• Comprehensive mastery of the drug development continuum, with proven success navigating clinical manufacturing, commercial process validation, combination product/device development, and post-approval Life Cycle Management.
• Demonstrated executive experience managing external/outsourced CMO networks globally.
• Strong technical understanding of cGMPs, FDA/EMA regulations, and global regulatory submission requirements.
• Exceptional executive presence, with the ability to manage complex internal team dynamics, mentor senior leaders, and communicate strategically with the Executive Management Team and external partners.

Working Conditions

Position may require periodic evening and weekend work, as necessary to fulfill obligations. Periodic overnight travel may be required. This position is based in Xeris' Chicago Headquarters and requires a minimum of four days per week in the office. On-site requirements may change at management's discretion.